Informasi Detail
| Call Number | : | 711 i p 2012 - 1 |
| Judul | : | Perbedaan Efek Profenofos dengan Diazinon terhadap Gambaran Makroskopis Dan Mikroskopis Jantung Tikus Putih (Rattus Norvegicus) Kajian Warna, Massa Jantung, Ketebalan Miokardium Ventrikel dan Gambaran |
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| Judul Seri | : | |
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| Pengarang | : | ISWATINNISA/08711123 DYNI PEMBIMBING: Nugraha Zainuri Sabta |
| Subyek | : | 1.EFEK PROFENOFOS 2.DIAZINON 3.MAKROSKOPIS |
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| Abstrak | : | Background : Profenofos and diazinon are organophosphate pesticide which numerous used.Some of the research showed hyperemis, congestive and pathological occured on several organs, such as brain, liver, and lungs in animals. Any study reseacrh about compare between the effects of profenofos with diazinon on the macroscopic and microscopic appearance of the heart is have not been studied yet. Purpose : To found the difference in macroscopic and microscopic appearance of the heart in white rats include colour change of heart and heart mass, heart muscle thickness of ventricle and histopathological appearance of heart. Method : This study used an experimental research design with post test only control group design. Samples taken randomly divided into three groups. Each group consisted of seven male rats. Group K (control) treated with 2 ml of distilled water. Group P1 treated with 1/10 LD50 (125 mg/kgBB) of diazinon and group P2 treated with 1/10 LD50 (107,5 mg/kgBB) of profenofos. Treated was given for 7 days. Data analysis used Oneway Anova and Post Hoc Test with SPSS 17.0. program. Results : In this study, heart colour in profenofos more dark than control and diazinon group. The result of statistical analysis oneway anova with confidence level at 95%, was obtained p=0,01 (p[0,05) for heart mass in profenofos and diazinon group, it showed significant difference. The heart muscle of left ventricle was obtained p=0,005 for thick of posterior wall between control-profenofos group, lateral wall between diazinon-profenofos group was obtained p=0,045, anterior wall between control and diazinon group was obtained p=0,002, and anterior wall between diazinon and profenofos was obtained p=0,035, as for heart muscle of right ventricle was obtained p=0,042 for posterior wall between diazinon-profenofos group. The histopathological of heart in treated group showed hemorragic, necrosis, and cell vacuoliation. In profenofos group found inflamation cell, such as lymphocyte, PMN, and mast cell. Conclusion : there is difference of profenofos effect with diazinon on colour change of heart, heart mass, heart muscle thickness of ventricle, histopathological appearance of heart which showed hemorragic and heart muscle damage. Keywords : profenofos, diazinon, heart colour, heart mass, and heart muscle thickness of ventricle, histopathological appearance of heart |
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| Lokasi | : | Perpustakaan Pusat UII |
| Jenis | : | Skripsi |
| DDC | : | 711 |
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| Penerbit | : | Fakultas Kedokteran UII |
| Tahun Terbit | : | 2012 |
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| ISBN / ISSN | : | / |
| Jumlah Eksemplar | : | 1 |
| Jumlah Tersedia | : | 0 |
| Jumlah Ditempat | : | 0 |
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| Informasi Digital | ||
| Abstrak | : | abstract.pdf |
| Cover | : | cover.pdf |
| Daftar isi | : | daftar isi.pdf |
| Preliminary | : | preliminari.pdf |