Informasi Detail
| Call Number | : | 613 Gus f |
| Judul | : | Formulasi Dan Evaluasi Patch Bukal Mukoadhesif Salbutamol Sulfat Dengan Basis Na-CMC dan PVP K-30 |
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| Judul Seri | : | |
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| Pengarang | : | GUSTRI ARDIANI PEMBIMBING: Mufrodhi Akhmad NUGROHO BAMBANG HERNAWAN |
| Subyek | : | 1.PATCH BUKAL 2.SALBUTAMOL SULFAT 3.POLIMER MUKOADHESIF 4.NA-CMC 5.PVP K-30 |
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| Abstrak | : | Salbutamol sulphate is a selective b2 adrenoceptor agonist compounds that undergo a process of first pass metabolism and has a low bioavailability ( 40 % ) in the oral use . One effort to boost the bioavailability of salbutamol sulphate is to formulate the mucoadhesive buccal patches dosage forms . Making the buccal patch is done by using the solvent casting method , using mucoadhesive polymers Na - CMC and PVP K - 30 . This study aims to determine the release of salbutamol sulphate , physical characteristics , and irritation of the mucoadhesive buccal patches with variations in the base levels of Na - CMC and PVP K - 30 . Buccal patch preparations were made with five levels of variation which formula I 100 % : 0 % ; formula II 75 % : 25 % ; formula III 50 % : 50 % ; formula IV 25 % : 75 % ; and the formula V 0 % : 100 % . Patch test results showed the combination of mucoadhesive polymers Na - CMC and PVP K - 30 affect the release of salbutamol sulphate , high concentrations of Na - CMC and the concentration of PVP K - 30 low can boost drug release . Formula II with a concentration ratio of Na - CMC : PVP K - 30 ( 75 % : 25 % ) showed the highest release the number of release 92.19 % . The combination of mucoadhesive polymers Na - CMC and PVP K - 30 affects the physical properties of the buccal patch , the higher the concentration of Na - CMC , the weight , swelling index , the greater thickness . Mucoadhesive buccal patches of salbutamol sulphate produced does not irritate the buccal mucosa with a total production of mucus produced less than 15 % . Keywords: Buccal patches, Salbutamol sulphate, Mucoadhesive polymers, Na-CMC and PVPK-30 |
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| Lokasi | : | Perpustakaan Pusat UII |
| Jenis | : | Skripsi |
| DDC | : | 613 |
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| Penerbit | : | Jurusan Farmasi FMIPA UII |
| Tahun Terbit | : | 2014 |
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| ISBN / ISSN | : | / |
| Jumlah Eksemplar | : | 0 |
| Jumlah Tersedia | : | 0 |
| Jumlah Ditempat | : | 0 |
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| Informasi Digital | ||
| Abstrak | : | abstract.pdf |
| Cover | : | cover.pdf |
| Daftar isi | : | daftar isi.pdf |
| Preliminary | : | preliminari.pdf |