Informasi Detail
| Call Number | : | 613 Hat f |
| Judul | : | Formulasi Dan Evaluasi Tablet Metformin HCI Lepas Lambat Dengan Sistem Floating Menggunakan Polimer HPMC K4M Dan Kitosan |
| Judul Asli | : | |
| Judul Seri | : | |
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| Pengarang | : | Hati Melati Permata PEMBIMBING: Syukri Yandi NUGROHO BAMBANG HERNAWAN |
| Subyek | : | 1.METFORMIN HCL 2.DIABETES MELITUS 3.LEPAS LAMBAT 4.SISTEM FLOATING |
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| Abstrak | : | The research aimed to prepare and evaluate of sustained release metformin HCl tablet with floating system. The tablets were prepared by wet granulation using HPMC K4M and chitosan as matrix with proportions (b/b) 17.78%:4.44%; 14.44%:7.78%; 11.11%:11.11% ;7.78%;14.44%; 4.44%:17.78%. The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and drug release studies. The dissolution study had been carried out for 6 hour using USP dissolution apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37?0.5%. All tablet formulas showed closed similarity with the requirement physical tablet of United State Pharmacopea (USP) and Farmakope Indonesia reference. The matrices containing higher HPMC K4M, and lower chitosan showed floating lag time decreased and duration time increased. Meanwhile, tablet disintegration is lowest. The release test showed that all formulas did not meet the requirements dissolution metformin HCl sustained release tablet. The result of this study is sustained release tablet metformin HCl with matrices HPMC K4M and chitosan is able to float, but it did not form sustained release. Key word: Metformin HCl, diabetes mellitus, sustained release, floating system |
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| Lokasi | : | Perpustakaan Pusat UII |
| Jenis | : | Skripsi |
| DDC | : | 613 |
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| Penerbit | : | Jurusan Farmasi FMIPA UII |
| Tahun Terbit | : | 2014 |
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| ISBN / ISSN | : | / |
| Jumlah Eksemplar | : | 0 |
| Jumlah Tersedia | : | 0 |
| Jumlah Ditempat | : | 0 |
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| Informasi Digital | ||
| Abstrak | : | abstract.pdf |
| Cover | : | cover.pdf |
| Daftar isi | : | daftar isi.pdf |
| Preliminary | : | preliminari.pdf |